Splicing components are excluded from the transcriptionally inactive XY body in male meiotic nuclei.
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چکیده
منابع مشابه
Ubiquitin ligase Rad18Sc localizes to the XY body and to other chromosomal regions that are unpaired and transcriptionally silenced during male meiotic prophase.
In replicative damage bypass (RDB) in yeast, the ubiquitin-conjugating enzyme RAD6 interacts with the ubiquitin ligase RAD18. In the mouse, these enzymes are represented by two homologs of RAD6, HR6a and HR6b, and one homolog of RAD18, Rad18Sc. Expression of these genes and the encoded proteins is ubiquitous, but there is relatively high expression in the testis. We have studied the subcellular...
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The Barr body has long been recognized as the cytological manifestation of the inactive X chromosome (Xi) in interphase nuclei. Despite being known for over 50 years, relatively few components of the Barr body have been identified. In this study, we have screened over 30 histone variants, modified histones and non-histone proteins for their association with or exclusion from the Barr body. We d...
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Der Aufbau des Nukleosoms als Grundbaustein des Chromatins der Eukaryontenzelle, mit Ausnahme des Dinoflagellaten-Zellkerns, wird biochemisch und elektronenmikroskopisch vorgestellt als eine Einheit eines Oktamers aus Histonen (2 X H2A, 2XH2B, 2X H3, 2X H4) und einem Betrag von etwa 150 Basenpaaren DNA. Diese Partikel sind durch einen Zwischenbereich von weiteren etwa 50 Basenpaaren DNA verbund...
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Sam68 plays an essential role in mouse spermatogenesis and male fertility. Herein, we report an interaction between Sam68 and the phosphorylated forms of the RNA polymerase II (RNAPII) in meiotic spermatocytes. RNase treatment decreased but did not abolish the interaction, consistently with in vitro binding of RNAPII to the Sam68 carboxyl-terminal region. Sam68 retention in the spermatocyte nuc...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 1994
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.5.12.1341